Virulence-Associated Proteins Capsular Polysaccharides and Acquired Antibodies to Pneumococcal Effects of Ageing and Gender on Naturally
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منابع مشابه
Expression of E.coli capsular polysaccharide requires the KfiB protein:A Structural based analysis
Abstract Background and objectives: important virulence factor for many invasive bacterial pathogens of humans. Escherichia coli offer a model system to study the mechanisms by which capsular polysaccharides are synthesized and exported onto the cell surface of bacteria. Biosynthesis of the E consists of the repeat structure -4) GlcA- (1, 4)-GlcNAc- (1-, requires the KfiA,...
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Streptococcus pneumoniae infection is a frequent cause of pneumonia, otitis media, meningitis, and septicemia. Pneumococcal surface protein A (PspA) is an important virulence factor on the pathogen surface, and it is known to interfere with complement activation. In this study, flow cytometry was used to study the effects of PspA and antibodies to PspA on the deposition of complement C3 on the ...
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Antibodies to capsular polysaccharide (PS) are protective against systemic infection by Streptococcus pneumoniae, but the large number of pneumococcal serogroups and the age-related immunogenicity of pure PS limit the utility of PS-based vaccines. In contrast, cell wall-associated proteins from different capsular serotypes can be cross-reactive and immunogenic in all age groups. Therefore, we e...
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Streptococcus pneumoniae is an opportunistic pathogen globally associated with significant morbidity and mortality. It is capable of causing a wide range of diseases including sinusitis, conjunctivitis, otitis media, pneumonia, bacteraemia, sepsis, and meningitis. While its capsular polysaccharide is indispensible for invasive disease, and opsonising antibodies against the capsule are the basis...
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Infants and very young children are poor responders to polysaccharide antigens (1-4) and fail to make protective antibody responses to a number of polysaccharide-containing vaccines including the 23-valent pneumococcal vaccine (2, 5) currently used to immunize adults (6). One way to attempt immunization of children against encapsulated bacteria is to modify the capsular polysaccharides so that ...
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